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Analysis on the distinguishing features of traditional Chinese therapeutics and related statistical issues

Jingqing Hu, Jie Qiao, Deying Kang, Baoyan Liu

《医学前沿（英文）》 2011年 第5卷 第2期   页码 203-207 doi: 10.1007/s11684-011-0138-6

摘要： Traditional Chinese medicine (TCM) is one of the rarely existing ancient traditional medicines that hold systematic theories as well as preventative and therapeutic methods for diseases in practice. From the 1950s, such research methods as mathematics, statistics, and data mining (DM) have been gradually introduced to TCM studies, making it more scientific. Meanwhile, the distinct features of TCM theories and diagnostic-model have constantly challenged the methodology of statistics. This paper introduces the following scientific features of traditional Chinese therapeutics: 1) its goal is to balance the functions and conditions of human body; 2) it emphasizes on holism and individualization; 3) it stresses the longitudinal regulation and evaluation mode, which is a circle of syndrome diagnosis, treatment and evaluation; 4) the interventions of TCM are abundant, compound and natural; and 5) humanistic thought is everywhere. Some statistical problems are raised based on these features. First, complex statistical methods that can analyze subjective indexes and latent variables, multidimensional and multistage data, non-equilibrium designed studies, and longitudinal data are required. Second, comprehensive evaluation on multiple-target mechanism has been brought in by combination treatment. Third, there is a need to analyze how humanity and related cultural factors may influence the effect of interventions. Thus, promoting implemented studies of statistics as well as carrying out the TCM scientific propositions have become the common expectations of both TCM and modern medicine.

关键词： traditional Chinese therapeutics     feature     statistic    

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Thermal and energy analysis of a Chinese kang

Zhi ZHUANG, Yuguo LI, Xudong YANG, Bin CHEN, Jiaping LIU,

《能源前沿（英文）》 2010年 第4卷 第1期   页码 84-92 doi: 10.1007/s11708-010-0009-x

摘要： About 67million Chinese kangs are still used by about 175million people in China today. The kang utilizes biomass burning for space heating and hence reduces the use of commercial energy. However, the existing design of kangs is largely based on the accumulated experience of craftsmen, for lack of scientific studies and engineering design guidelines. Poor construction of kangs also leads to serious indoor air pollution. In this paper, a macroscopic smoke flow and heat transfer model of an elevated kang is integrated in a widely-used building energy analysis software in China–DeST, and the integrated software can be used for the thermal performance analysis of kang-integrated houses. A typical house with kangs in various villages of northern China is chosen as a case study. The annual performance of the kang under different insulations of building envelope and climatic conditions are discussed. Based on the simulation results, it is found that the thermal comfort requirement of the outside surface of the upper kang plate can be met by a proper construction of the kang and selection of the appropriate firing pattern. The better the insulation of the building envelope is or the better the room air tightness is, the greater the indoor air temperature rise and the greater the building heating load contribution of the kang. In the eight selected cities in northern China, the use of kang can meet 50%–80% of the house heating load.

关键词： Chinese kang     elevated kang     rural house thermal modeling     building energy efficiency     DeST    

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Applications of dynamical complexity theory in traditional Chinese medicine

null

《医学前沿（英文）》 2014年 第8卷 第3期   页码 279-284 doi: 10.1007/s11684-014-0367-6

摘要：

Traditional Chinese medicine (TCM) has been gradually accepted by the world. Despite its widespread use in clinical settings, a major challenge in TCM is to study it scientifically. This difficulty arises from the fact that TCM views human body as a complex dynamical system, and focuses on the balance of the human body, both internally and with its external environment. As a result, conventional tools that are based on reductionist approach are not adequate. Methods that can quantify the dynamics of complex integrative systems may bring new insights and utilities about the clinical practice and evaluation of efficacy of TCM. The dynamical complexity theory recently proposed and its computational algorithm, Multiscale Entropy (MSE) analysis, are consistent with TCM concepts. This new system level analysis has been successfully applied to many health and disease related topics in medicine. We believe that there could be many promising applications of this dynamical complexity concept in TCM. In this article, we propose some promising applications and research areas that TCM practitioners and researchers can pursue.

关键词： traditional Chinese medicine     Multiscale Entropy     dynamical complexity     system level     applications    

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Mutation analysis of KCNQ1, KCNH2, SCN5A, KCNE1 and KCNE2 genes in Chinese patients with long QT syndrome

DU Rong, TIAN Li, YUAN Guohui, LI Jin, REN Faxin, GUI Le, LI Wei, ZHANG Shouyan, KANG Cailian, YANG Junguo

《医学前沿（英文）》 2007年 第1卷 第3期   页码 312-315 doi: 10.1007/s11684-007-0060-0

摘要： Long QT syndrome (LQTS) is the prototype of the cardiac ion channelopathies, which cause syncope and sudden death. Inherited LQTS is represented by the autosomal dominant Romano-ward syndrome (RWS), which is not accompanied by congenital deafness, and the autosomal recessive Jervell and Lange-Nielsen syndrome (JLNS), which is accompanied by congenital deafness. The LQTS-causing mutations have been reported in patients and families from Europe, North America and Japan. Few genetic studies have been carried out in families with JLNS from China. This study investigates the molecular pathology in four families with LQTS (including a family with JLNS) in the Chinese population. Polymerase chain reaction and DNA sequencing were used to screen for , , , and mutation. A missense mutation G314S in an RWS family was identified, and a single nucleotide polymorphism (SNP) G643S was indentified in the of the JLNS family. In this JLNS family, another heterozygous novel mutation in exon 2a was found in of the patients. Our data provide useful information for the identification of polymorphisms and mutations related to LQTS and the Brugada Syndrome (BS) in Chinese populations.

关键词： recessive Jervell     LQTS-causing     population     autosomal dominant     syndrome    

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Deciphering the pharmacological mechanism of Guan-Jie-Kang in treating rat adjuvant-induced arthritis

Hudan Pan, Yanfang Zheng, Zhongqiu Liu, Zhongwen Yuan, Rutong Ren, Hua Zhou, Ying Xie, Liang Liu

《医学前沿（英文）》 2019年 第13卷 第5期   页码 564-574 doi: 10.1007/s11684-018-0676-2

摘要： Traditional Chinese medicine (TCM) formulas have attracted increasing attention worldwide in the past few years for treating complex disease including rheumatoid arthritis. However, their mechanisms are complex and remain unclear. Guan-Jie-Kang (GJK), a prescription modified from “Wu Tou Decoction,” was found to significantly relieve arthritis symptoms in rats with adjuvant-induced arthritis after 30-day treatment, especially in the 24 g/kg/day group. By analyzing 1749 targets related to 358 compounds in the five herbs of GJK, we identified the possible anti-arthritis pathways of GJK, including the calcium signaling and metabolic pathways. Bone damage levels were assessed by micro-computed tomography, and greater bone protective effect was observed with GJK treatment than with methotrexate. Receptor activator of nuclear factor κB ligand (RANKL)–RANK signaling, which is related to calcium signaling, was significantly regulated by GJK. Moreover, a target metabolomics assay of serum was conducted; 17 metabolic biomarkers showed significant correlations with treatment. An integrated pathway analysis revealed that pyruvate metabolism, purine metabolism, and glycolysis metabolism were significantly associated with the effects of GJK in arthritis treatment. Thus, this study establishes a new omics analytical method integrated with bioinformatics analysis for elucidating the multi-pathway mechanisms of TCM.

关键词： rheumatoid arthritis     traditional Chinese medicine     pharmacological mechanism     metabolism     adjuvant-induced arthritis     omics analysis    

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Ant colony optimization in continuous problem

YU Ling, LIU Kang, LI Kaishi

《机械工程前沿（英文）》 2007年 第2卷 第4期   页码 459-462 doi: 10.1007/s11465-007-0079-6

摘要： Based on the analysis of the basic ant colony optimization and optimum problem in a continuous space, an ant colony optimization (ACO) for continuous problem is constructed and discussed. The algorithm is efficient and beneficial to the study of the ant colony optimization in a continuous space.

关键词： beneficial     algorithm     efficient     continuous     ACO    

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Recent progress in the design and fabrication of MXene-based membranes

Kai Qu, Kang Huang, Zhi Xu

《化学科学与工程前沿（英文）》 2021年 第15卷 第4期   页码 820-836 doi: 10.1007/s11705-020-1997-7

摘要： Two-dimensional membranes have attracted significant attention due to their superior characteristics, and their ability to boost both flux and selectivity have led to their reputation as potential next-generation separation membranes. Among them, emerging MXene-based membranes play significant roles in the competitive membrane-separation field. In this mini-review, we systematically discuss the assembly and separation mechanisms of these membranes. Moreover, we highlight strategies based on the crosslinking of MXene nanosheets and the construction of additional nanochannels that further enhance the permeabilities and anti-swelling properties of MXene-based membranes and meet the requirements of practical applications, such as gas-molecule sieving, ion sieving, and other small-molecule sieving. MXene nanosheets can also be used as additives that introduce specific functionalities into hybrid membranes. In addition, extended applications that use MXenes as scaffolds are also discussed.

关键词： MXene     2D materials     membranes     separation    

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Steps of fronts in chemical engineering: An overview of the publications of FCSE

Xiaowen Zhu, Yaodong Huang, Jing-Kang Wang

《化学科学与工程前沿（英文）》 2018年 第12卷 第4期   页码 593-597 doi: 10.1007/s11705-018-1789-5

摘要：
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DsbA-DsbA

Ye Liu,Wenyong Zhang,Xubin Yang,Guangbo Kang,Damei Wang,He Huang

《化学科学与工程前沿（英文）》 2015年 第9卷 第4期   页码 511-521 doi: 10.1007/s11705-015-1519-1

摘要： A co-expressing system of DsbA-DsbA was suggested for the first time to enhance the soluble expression of human trypsin-1. As a control, leaderless DsbA chaperone was also co-expressed with human trypsin-1. Vectors pET39b-trypsin and pET28a-DsbA-DsbA -trypsin with the above two DsbA fusion tag were constructed. The strain with vector pET39b-trypsin expressed fusion protein DsbA-trypsin in form of inclusion bodies. While in BL21 (DE3) strain with vector pET28a-DsbA-DsbA -trypsin, the soluble expression of trypsin fusion protein was achieved. Under the optimized expression conditions, the soluble fraction accounted for about 49.43% of total DsbA-DsbA -trypsin proteins in crude supernatant. The purification yield was 4.15% by nickel chelating chromatography and 3.3 mg activated trypsin with a purity of 88.68% was obtained from 1 L LB broth. To detect the possible functions of DsbA series chaperons in trypsin fusion protein, we analyzed the primary three-dimensional structure of fusion proteins, mainly focusing on the compatibleness between trypsin and fusion chaperons. The results suggested that (1) besides the primary function in periplasm, leaderless DsbA or DsbA may also act as a signal sequences-like leader targeted to periplasm that partly relieved the pressure from fusion protein overexpression and inclusion body formation, and (2) as there was significant soluble expression of DsbA-DsbA -trypsin compared with DsbA-trypsin, DsbA may function as charge or hydrophobic balance in recombinant protein DsbA-DsbA -trypsin.

关键词： DsbA     DsbA-DsbAmut     soluble expression     trypsin     chaperon    

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Statistical considerations for genomic selection

Huimin KANG, Lei ZHOU, Jianfeng LIU

《农业科学与工程前沿（英文）》 2017年 第4卷 第3期   页码 268-278 doi: 10.15302/J-FASE-2017164

摘要： Genomic selection is becoming increasingly important in animal and plant breeding, and is attracting greater attention for human disease risk prediction. This review covers the most commonly used statistical methods and some extensions of them, i.e., ridge regression and genomic best linear unbiased prediction, Bayesian alphabet, and least absolute shrinkage and selection operator. Then it discusses the measurement of the performance of genomic selection and factors affecting the prediction of performance. Among the measurements of prediction performance, the most important and commonly used measurement is prediction accuracy. In simulation studies where true breeding values are available, accuracy of genomic estimated breeding value can be calculated directly. In real or industrial data studies, either training-testing approach or -fold cross-validation is commonly employed to validate methods. Factors influencing the accuracy of genomic selection include linkage disequilibrium between markers and quantitative trait loci, genetic architecture of the trait, and size and composition of the training population. Genomic selection has been implemented in the breeding programs of dairy cattle, beef cattle, pigs and poultry. Genomic selection in other species has also been intensively researched, and is likely to be implemented in the near future.

关键词： genomic estimated breeding value     genomic selection     linkage disequilibrium     statistical methods    

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Contributions in renewable energy systems: A perspective from the latest publications of FCSE

Xiaowen Zhu, Di Xu, Jing-Kang Wang

《化学科学与工程前沿（英文）》 2019年 第13卷 第4期   页码 632-635 doi: 10.1007/s11705-019-1904-2

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Theoretical and experimental analysis on super precision grinding of monocrystal silicon

GUO Xiaoguang, GUO Dongming, KANG Renke, JIN Zhuji

《机械工程前沿（英文）》 2007年 第2卷 第2期   页码 137-143 doi: 10.1007/s11465-007-0023-9

摘要： Through investigating the diamond-silicon grinding system, the grinding mechanism, including chip removal and subsurface damage, is discussed with the aid of the molecular dynamics (MD) approach and grinding experiments. Based on MD simulation, nanometric-grinding mechanism is analyzed from the viewpoint of instantaneous distribution of atoms, grinding force, and the potential energy between atoms and the profile of the groove. The simulation results show that some silicon atoms are deformed and piled up in front and on two sides of the abrasive surface because of the extrusion and cutting. When the energy in silicon lattice reaches its maximum value, the bonds of silicon atoms are broken and the material is removed. With the advancement of the abrasive, the silicon lattice under the abrasive surface is fractured, and then the amorphous layers are formed and propagated, which causes the subsurface damage. At the same time, some amorphous atoms are reconstructed and the degenerating layer of the machined surface is formed. Besides, the recovery of elatstic deformation occurs in the machined surface of the workpiece. In addition, the grinding experiment and profile detection with the aid of the measurment for 3D profiling are performed to verify the simulation results. The good agreement in the profile of the groove between the experimental value and the simulating value shows that MD simulation is very effective and reliable, and successful to fulfill the investigation on nanometric machining mechanism.

关键词： machining mechanism     recovery     advancement     mechanism     subsurface    

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Practice and principle of traditional Chinese medicine for the prevention and treatment of COVID-19

《医学前沿（英文）》 doi: 10.1007/s11684-023-1040-8

摘要： Traditional Chinese medicine (TCM) has played an important role in the prevention and treatment of coronavirus disease 2019 (COVID-19) epidemic in China. The integration of Chinese and Western medicine is an important feature of Chinese COVID-19 prevention and treatment. According to a series of evidence-based studies, TCM can reduce the infection rate of severe acute respiratory syndrome coronavirus 2 in high-risk groups. For patients with mild and moderate forms of COVID-19, TCM can relieve the related signs and symptoms, shorten the period of nucleic-acid negative conversion, and reduce conversion rate to the severe form of the disease. For COVID-19 patients with severe and critical illnesses, TCM can improve inflammatory indicators and blood oxygen saturation, shorten the hospital stay, and reduce the mortality rate. During recovery, TCM can improve patients’ symptoms, promote organ function recovery, boost the quality of patients’ life, and reduce the nucleic-acid repositive conversion rate. A series of mechanism research studies revealed that capability of TCM to treat COVID-19 through antiviral and anti-inflammatory effects, immune regulation, and protection of organ function via a multicomponent, multitarget, and multipathway approach.

关键词： traditional Chinese medicine     COVID-19     SARS-CoV-2     clinical evidence-based study     mechanism     integrated traditional Chinese and Western medicine    

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Practices, challenges, and opportunities: HIV/AIDS treatment with traditional Chinese medicine in China

Jian Wang, Wen Zou

《医学前沿（英文）》 2011年 第5卷 第2期   页码 123-126 doi: 10.1007/s11684-011-0124-z

摘要： Traditional Chinese medicine (TCM) has become widely used in the treatment of acquired immune deficiency syndrome (AIDS) in China in recent years. In this article, we summarize the recent major developments in human immunodeficiency virus/AIDS (HIV/AIDS) treatment with TCM. The use of TCM is associated with preventing or alleviating HIV-related symptoms, reducing treatment side effects, and improving the quality of life. The potential beneficial effects of TCM should be confirmed through extensive and rigorous trials.

关键词： HIV/AIDS     traditional Chinese medicine    

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Individualized medicine, health medicine, and constitutional theory in Chinese medicine

null

《医学前沿（英文）》 2012年 第6卷 第1期   页码 1-7 doi: 10.1007/s11684-012-0173-y

摘要：

The patterns of modern science and changes in the medical model can result in the transformation of the current state of individualized and health medicines into being the primary trend in medical development. Chinese and Western medical systems are dissimilar in terms of value orientations, thinking style, and research directions because of their different historical and cultural backgrounds. Individualized treatment in modern medicine is mainly established based on individual genome information and the differences in mononucleotide polymorphi-sms. However, such treatment method is expensive, creates an uncertain genetic marker, and leads to different result interpretations, among other problems. The Chinese constitutional theory developed in the 1970s expresses the principle behind Chinese health medicine and individual treatment and provides the corresponding methods. The Chinese constitutional theory divides the constitution of the Chinese population into nine categories based on established classification criteria. It promotes the study of the relationship of each constitution to diseases and Chinese medicine preparation toward adjusting the constitution and preventing diseases. The theory also provides methods and tools for individualized treatment. Constitution identification shows the direction and provides the core technology for the evaluation of the health status. By combining the developments in modern biotechnology, new diagnostic techniques and treatment models of constitution-differentiation, disease-differentiation, and syndrome-differentiation can be established for the development of individualized Chinese medicine treatment and health medicine for the international medical community.

关键词： individualized medicine     health medicine     constitutional theory in Chinese medicine    

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标题 作者 时间 类型 操作

Analysis on the distinguishing features of traditional Chinese therapeutics and related statistical issues

Jingqing Hu, Jie Qiao, Deying Kang, Baoyan Liu

期刊论文

Thermal and energy analysis of a Chinese kang

Zhi ZHUANG, Yuguo LI, Xudong YANG, Bin CHEN, Jiaping LIU,

期刊论文

Applications of dynamical complexity theory in traditional Chinese medicine

null

期刊论文

Mutation analysis of KCNQ1, KCNH2, SCN5A, KCNE1 and KCNE2 genes in Chinese patients with long QT syndrome

DU Rong, TIAN Li, YUAN Guohui, LI Jin, REN Faxin, GUI Le, LI Wei, ZHANG Shouyan, KANG Cailian, YANG Junguo

期刊论文

Deciphering the pharmacological mechanism of Guan-Jie-Kang in treating rat adjuvant-induced arthritis

Hudan Pan, Yanfang Zheng, Zhongqiu Liu, Zhongwen Yuan, Rutong Ren, Hua Zhou, Ying Xie, Liang Liu

期刊论文

Ant colony optimization in continuous problem

YU Ling, LIU Kang, LI Kaishi

期刊论文

Recent progress in the design and fabrication of MXene-based membranes

Kai Qu, Kang Huang, Zhi Xu

期刊论文

Steps of fronts in chemical engineering: An overview of the publications of FCSE

Xiaowen Zhu, Yaodong Huang, Jing-Kang Wang

期刊论文

DsbA-DsbA

Ye Liu,Wenyong Zhang,Xubin Yang,Guangbo Kang,Damei Wang,He Huang

期刊论文

Statistical considerations for genomic selection

Huimin KANG, Lei ZHOU, Jianfeng LIU

期刊论文

Contributions in renewable energy systems: A perspective from the latest publications of FCSE

Xiaowen Zhu, Di Xu, Jing-Kang Wang

期刊论文

Theoretical and experimental analysis on super precision grinding of monocrystal silicon

GUO Xiaoguang, GUO Dongming, KANG Renke, JIN Zhuji

期刊论文

Practice and principle of traditional Chinese medicine for the prevention and treatment of COVID-19

期刊论文

Practices, challenges, and opportunities: HIV/AIDS treatment with traditional Chinese medicine in China

Jian Wang, Wen Zou

期刊论文

Individualized medicine, health medicine, and constitutional theory in Chinese medicine

null

期刊论文